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  • Title: Stimulation of human monocyte/macrophage-derived growth factor (MDGF) production by plasma fibronectin.
    Author: Martin BM, Gimbrone MA, Majeau GR, Unanue ER, Cotran RS.
    Journal: Am J Pathol; 1983 Jun; 111(3):367-73. PubMed ID: 6859221.
    Abstract:
    Culture supernatants from human peripheral blood monocytes, isolated free of platelet contamination and cultured in the absence of serum, stimulate DNA synthesis and cell growth in Balb/c 3T3 fibroblasts and bovine aortic smooth-muscle cells. Monocytes cultured in serum-free medium for 24 hours with plasma fibronectin, added as either a surface-attached or soluble molecule, secrete significantly increased amounts of growth-promoting activity. Fibronectin also stimulates an increase in intracellular growth factor content and in protein synthesis by monocytes. Both the enhanced growth-promoting activity and protein synthesis are inhibited by cycloheximide. Thus, fibronectin-monocyte interactions may influence the production of growth-promoting activity by monocytes and contribute to fibroblast and smooth-muscle replication in wound healing, chronic inflammation and atherosclerosis.
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