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  • Title: Effect of subcutaneous desferrioxamine on iron balance in young thalassemia major patients.
    Author: De Virgiliis S, Cossu P, Toccafondi C, Sanna G, Frau F, Lobrano R, Cornacchia G, Nucaro A, Loi A, Bertolino F, Cao A.
    Journal: Am J Pediatr Hematol Oncol; 1983; 5(1):73-7. PubMed ID: 6859457.
    Abstract:
    In this study we evaluated the effect of 1-year, subcutaneous desferrioxamine daily infusion on iron balance in 23 thalassemia major children, aged 8-74 months, with transfusional iron accumulation less than 3.8 g at the outset of the trial. Statistical analysis showed a significant correlation between transfusional iron accumulation and percentage of transfusional iron eliminated. Confidence limits analysis of these data indicated that over 3.5 g of transfusional iron load, 95% of the patients may achieve balance. The appropriate time to begin desferrioxamine infusion, therefore, seems to be after about 30 transfusions of packed red blood cells when iron accumulation of approximately 3 g is reached. As we found a statistically significant correlation between transfusional iron eliminated and serum ferritin levels, the evaluation of serum ferritin alone can also predict when balance can be obtained.
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