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  • Title: [Tolerability of an aromatic retinoid (RO 10 9359, etretinate, Tigason, Roche). Research on its toxicity on hematopoietic, renal and thyroid functions. Interactions with the metabolism of natural retinoids].
    Author: Fontan B, Bonafé JL, Moatti JP.
    Journal: Ann Dermatol Venereol; 1983; 110(1):23-31. PubMed ID: 6859752.
    Abstract:
    59 patients with keratinisation diseases have been received RO 10 9359. There is a clinical medicum tolerance. Biologic controls have been carried out before and after a 3 month treatment. There is a good biological tolerance for the hematopoietic, glucidic, renal and thyroid functions. Thus the hepatic tolerance is poor for the patients with a predisposition for hepatic diseases (plethorics, alcoholics).
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