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  • Title: [Experimental study of the dynamics of the biochemical indices of the lymph after kefzol and amphotericin B administration].
    Author: Polosova RG, Balashev VN.
    Journal: Antibiotiki; 1983 Apr; 28(4):289-94. PubMed ID: 6859827.
    Abstract:
    Antibiotics belonging to different groups i. e. amphotericin B of the neoaromatic group of heptaene antibiotics and kefzol, a cephalosporin antibiotic were studied with respect to their effect on some biochemical indices of the lymph and blood serum of experimental animals. Amphotericin B was administered intravenously in a dose of 1000 unit/kg once or daily for 5 days. Kefzol (sodium cephazoline) was administered intramuscularly in a single dose of 100 mg/kg. When the antibiotics were used in single doses, the lymph samples were collected from the thoracic duct 1 and 24 hours after the administration. On the repeated use of the antibiotic the samples were collected 24 hours after the last injection. The following biochemical indices were determined: the level of total protein, the ratio of the protein fractions (albumins, alpha 1-, alpha 2, beta- and gamma-globulins), the contents of urea, urea nitrogen, residual nitrogen, total, free and bound cholesterol. The esterification and albumin-globulin coefficients were estimated. The study revealed an analogy in the character of the changes in the above indices of the lymph and blood serum of the rabbits. However, there were also less pronounced changes in the above indices of the blood serum as compared to those in the lymph of the same animals.
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