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Title: Influence of vitamin A on the formation of ethylnitrosourea (ENU)-induced leukemias. Author: Wrba H, Dutter A, Hacker-Rieder A. Journal: Arch Geschwulstforsch; 1983; 53(2):89-92. PubMed ID: 6860090. Abstract: In mice, administration of ethylnitrosourea (120 mg/kg body weight) on day 14 of pregnancy leads to a transplacentally induced and transplantable leukemia in a high percentage of the offspring. Moreover, 100% of the offspring develop, later on, adenomas of the lung. Application of retinol palmitate (daily dose 170,000 IU/kg) reduces leukemogenesis up to 50%, yet without influencing formation of lung adenomas.[Abstract] [Full Text] [Related] [New Search]