These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Immunosuppression with cyclosporine. A new approach to improve patency of venous allografts.
    Author: Bandlien KO, Toledo-Pereyra LH, MacKenzie GH, Choudhury SP, Cortez JA.
    Journal: Arch Surg; 1983 Jul; 118(7):829-33. PubMed ID: 6860131.
    Abstract:
    In cases in which an autogenous vein is not available, the venous allograft still represents an interesting alternative; however, early occlusion of the allograft is the rule. Forty-five mongrel dogs received jugular allografts transplanted into the carotid artery. Group 1 (n = 6) received no immunosuppression; group 2 (n = 5) received systemic azathioprine (2.5 mg/kg/day). In group 3 (n = 10) the grafts were pretreated with cyclosporine at 4 degrees C, and in group 4 (n = 9) the grafts were cryopreserved in a solution of 15% dimethyl sulfoxide and cyclosporine (50 mg/L) at -196 degrees C prior to implantation. Groups 3 and 4 received azathioprine as in group 2. Group 5 received cyclosporine systemically (15 to 20 mg/kg/day). Patency rates at one month (groups 1 and 2, 0%; group 3, 57.1%; groups 4 and 5, 100%) indicate that cyclosporine improves venous allograft survival both when used systemically and as a graft pretreatment modality.
    [Abstract] [Full Text] [Related] [New Search]