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  • Title: On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid.
    Author: Mengs U.
    Journal: Arch Toxicol; 1983 Mar; 52(3):209-20. PubMed ID: 6860143.
    Abstract:
    The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.
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