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  • Title: Suppression of specific MLC responsiveness during skin allograft rejection in rats.
    Author: Wonigeit K, Pichlmayr R.
    Journal: Transplant Proc; 1977 Mar; 9(1):765-70. PubMed ID: 68602.
    Abstract:
    During the effector phase of allograft rejection a specific MLC unresponsiveness of PBL has been observed in skin-grafted rats. This unresponsiveness is caused by a suppressive effect that is dependent on a cooperative interaction between macrophages and alloantigen-activated T cells. The interaction is mediated by a soluble factor released from the alloantigen-activated T cells on exposure to the specific antigen. The suppression itself is nonspecific.
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