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  • Title: Metabolic changes at the margin of the spreading psoriatic lesion.
    Author: van de Kerkhof PC, van Rennes H, de Grood R, Bauer FW, Mier PD.
    Journal: Br J Dermatol; 1983 Jun; 108(6):647-52. PubMed ID: 6860560.
    Abstract:
    Keratotome slices were cut across the margins of rapidly-spreading psoriatic plaques. Each slice was divided into eight sections and in each section we measured the percentage cells in S phase and the levels of glucose-6-phosphate dehydrogenase (both related to epidermal proliferation), acid phosphatase (associated with keratinization) and alkaline phosphatase (a marker for dermal capillaries). Disturbances in the epidermis extended only 2 to 4 mm into the 'uninvolved' skin, whereas the capillaries were metabolically abnormal for a distance of about 2 cm ahead of the advancing edge of the plaque. This implies that changes in the capillary may precede those in the epidermis during the spread of the psoriatic lesion.
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