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  • Title: Liver cytosolic fatty acid-binding proteins. Effect of diabetes and starvation.
    Author: Brandes R, Arad R.
    Journal: Biochim Biophys Acta; 1983 Feb 07; 750(2):334-9. PubMed ID: 6860686.
    Abstract:
    The binding of [1-(14)C]oleate to rat liver cytosol was studied, using gel filtration on Sephadex G-75 and G-50. In liver cytosols from control rats, most of the high-affinity oleate binding was in the region of 12 000-dalton proteins. In liver cytosols from diabetic and starved rats, a second peak of radioactivity appeared in the void volume. This peak was shown to be associated with a component having the molecular weight of 400 000. Evidence suggesting that a change in the composition of cytosolic binding proteins is involved is presented.
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