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  • Title: Chronic D-amphetamine and phencyclidine: effects on dopamine agonist and antagonist binding sites in the extrapyramidal and mesolimbic systems.
    Author: Robertson HA.
    Journal: Brain Res; 1983 May 09; 267(1):179-82. PubMed ID: 6860944.
    Abstract:
    Dopamine agonist and antagonist binding to rat striatal and mesolimbic region tissue was examined in rats chronically treated with D-amphetamine or phencyclidine. In striatum, D-amphetamine produces a down-regulation of [3H]spiroperidol binding but an increase in [3H]ADTN bound (measured in the absence of ascorbate). This suggests that [3H]spiroperidol and [3H]ADTN bind to distinct, separate sites which can be independently regulated.
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