These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Age-related changes in electrophysiological properties of canine Purkinje fibers: effect of ouabain.
    Author: Gaum WE, Lathrop DA, Kaplan S.
    Journal: Dev Pharmacol Ther; 1983; 6(3):145-56. PubMed ID: 6861600.
    Abstract:
    Transmembrane potentials were recorded in Purkinje fibers obtained from dogs aged 1 day, 1 week, 2 weeks, 4 weeks and more than 1 year. After the initial impalements there was a time-dependent increase in diastolic potential. This hyperpolarization was more pronounced in the younger Purkinje fibers. Maximum diastolic potentials from 1-day-old puppies (-78.0 +/- 1.2 mV), after 10 min of continuous impalement, were significantly less negative than those for adults (-84.2 +/- 1.9 mV). Fibers from neonates exposed to ouabain do not depolarize as much as fibers from adults.
    [Abstract] [Full Text] [Related] [New Search]