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  • Title: Calcium-independent release of [3H]dopamine by veratridine in pargyline- and reserpine-treated corpus striatum.
    Author: Liang NY, Rutledge CO.
    Journal: Eur J Pharmacol; 1983 Apr 22; 89(1-2):153-5. PubMed ID: 6861884.
    Abstract:
    Veratridine produced a dose-dependent release of cytoplasmic [3H]dopamine in rat corpus striatal slices. Cytoplasmic [3H]dopamine was obtained by pretreating rats with reserpine to inhibit vesicular storage and incubating with pargyline and beta-thujaplicin to inhibit catabolism prior to incubation with [3H]dopamine. Release of [3H]dopamine by veratridine is absolutely calcium-independent and can be abolished by 10(-4) M tetrodotoxin and inhibited by 10(-5) M nomifensine. These results suggest that veratridine can release cytoplasmic [3H]dopamine by a carrier-mediated process.
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