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  • Title: [Comparative study of the activity of anti-arrhythmia agents in calcium chloride-induced arrhythmia in mice].
    Author: Gorbunova VV, Gorbunov NP.
    Journal: Farmakol Toksikol; 1983; 46(3):48-50. PubMed ID: 6861988.
    Abstract:
    Calcium chloride (280 mg/kg intravenously) provokes arrhythmia, heart fibrillation and death of mice. Pretreatment with isoptin, etmozine, lidocaine, trimecaine, quinidine and novocainamide prevents rhythm disorders and animals' death. Isoptin, etmozine, lidocaine and trimecaine have been found the most effective. Atropine does not produce any protective action. The simplicity and availability of the method described enables one to apply it as a model for search of new antiarrhythmic drugs.
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