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  • Title: [Non-steroidal anti-inflammatory agents. Stereoisomers of homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid. XII].
    Author: Burnelli S, Guarnieri A, Varoli L, Cesaroni MR, Scapini G.
    Journal: Farmaco Sci; 1983 May; 38(5):340-51. PubMed ID: 6862004.
    Abstract:
    The synthesis of some homologues of 2-(4-biphenylyl)-3-hydroxypropionic acid, the separation of related diastereoisomers, their attribution to erythro and threo series, and resolution of the optical antipodes are described. The antiinflammatory activity--initially tested by carrageenin assay--proves generally influenced by steric configuration and is interesting for the isohexanoic derivative.
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