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  • Title: The distribution and interaction of haemoglobin variants and the beta thalassaemia gene in Liberia.
    Author: Bienzle U, Komp H, Feldheim M, Reimer A, Steffen E, Guggenmoos-Holzmann I.
    Journal: Hum Genet; 1983; 63(4):400-3. PubMed ID: 6862445.
    Abstract:
    In a population survey in Liberia, West Africa, 12 major tribes were examined for the prevalence of Hb S, Hb C, and the beta thalassaemia (beta Thal) gene. Hb C is rare; Hb S and beta Thal occur in polymorphic frequencies. The distribution of both genes shows an inverse correlation. The beta Thal trait was diagnosed by quantitation of Hb A2 on DE 52-microchromatography. This method proved to be reliable and useful for mass screening.
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