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  • Title: In vitro and in vivo evaluation of two preparations of activated charcoal as adsorbents of aspirin.
    Author: Dawling S, Chand S, Braithwaite RA, Crome P.
    Journal: Hum Toxicol; 1983 Apr; 2(2):211-6. PubMed ID: 6862463.
    Abstract:
    1 The adsorptive capacities of two preparations of activated charcoal have been studied both in vitro and in vivo using aspirin as a test compound. 2 The in vitro adsorptive capacities of the charcoal preparations were 477 mg of acetylsalicylic acid/g effervescent charcoal ('Medicoal'); 359 mg/g untreated standard charcoal ('Norit-A') and 482 mg/g reheated charcoal ('Norit A'). 3 In vivo both charcoal preparations significantly reduced peak salicylate concentrations and salicylate availability, to a similar extent (analysis of variance P less than 0.001). 4 Both charcoal preparations have similar capacities for adsorbing aspirin both in vitro and in vivo.
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