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  • Title: The effects of D-penicillamine on non-immune responses to tissue injury.
    Author: Sedgwick AD, Edwards JC, Willoughby DA.
    Journal: Int J Tissue React; 1983; 5(1):11-7. PubMed ID: 6862785.
    Abstract:
    D-penicillamine was found to have a pro-inflammatory effect when given to rats during the formation of carrageenan air pouch granulomas or simple air cavity linings. Unlike dexamethasone, D-penicillamine had no effect on the strength of the cavity lining in either system. D-penicillamine had no effect on the chemoattractant properties of the carrageenan-induced exudates or on the responsiveness of cells from such exudates to a chemoattractant. These results suggest that D-penicillamine has a short-term pro-inflammatory effect on non-immune responses to tissue injury, but the mechanism remains unclear.
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