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  • Title: Endotoxaemia in septic shock: clinical and post mortem correlations.
    Author: McCartney AC, Banks JG, Clements GB, Sleigh JD, Tehrani M, Ledingham IM.
    Journal: Intensive Care Med; 1983; 9(3):117-22. PubMed ID: 6863720.
    Abstract:
    The Limulus amoebocyte lysate assay was used as one of a series of laboratory and clinical investigations on a group of 31 patients suffering from septic shock in order to assess the clinical significance of this assay for the detection of circulating endotoxin in clinical gram-negative sepsis. Four patients with cardiogenic shock served as controls. Endotoxin was detected in the bloodstream of all patients with septic shock during the 24 h following referral and was not detected in the control patients. Eventual clinical recovery was associated with the disappearance of endotoxin from the peripheral blood. Blood cultures were unhelpful as a prognostic indicator in these critically ill patients. A quantitative assay of endotoxin in blood may allow a more precise relationship with the clinical manifestations of major sepsis.
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