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  • Title: Kawasaki syndrome in an adult: endomyocardial histology and ventricular function during acute and recovery phases of illness.
    Author: Marcella JJ, Ursell PC, Goldberger M, Lovejoy W, Fenoglio JJ, Weiss MB.
    Journal: J Am Coll Cardiol; 1983 Aug; 2(2):374-8. PubMed ID: 6863771.
    Abstract:
    Kawasaki syndrome, an acute systemic inflammatory illness of unknown origin usually affecting children, may develop into a serious illness complicated by coronary artery aneurysms or myocarditis. This report describes an adult with Kawasaki syndrome studied by right ventricular endomyocardial biopsy and cardiac catheterization during the acute and recovery phases of illness. The initial biopsy specimen showed acute myocarditis and was associated with hemodynamic evidence of biventricular dysfunction, a severely depressed left ventricular ejection fraction and global hypokinesia. With time, there was spontaneous and rapid resolution of the inflammatory cell infiltrate with concurrent return to normal myocardial function. Right ventricular endomyocardial biopsy studies early in the course of the cardiac disease associated with Kawasaki syndrome may correlate with ventricular function and may be useful for monitoring immunosuppressive therapy in patients with this syndrome.
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