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  • Title: A quantitative study of nuclear DNA of trophoblastic cells analysis of nuclear DNA distribution and clinical outcome of hydatidiform mole.
    Author: Kashimura Y.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1983 May; 35(5):699-705. PubMed ID: 6864028.
    Abstract:
    Microspectrophotometric measurements of the nuclear DNA contents of Feulgen-stained trophoblastic cells were made in the cases of 54 normal pregnancies, 10 missed abortions, 118 hydatidiform moles, 11 invasive moles, and 9 choriocarcinomas. The position of the main peak and the range of nuclear DNA distribution correlated well with the severity of the trophoblastic disease. A statistically significant correlation was found between the position of the main peak and the occurrence of secondary trophoblastic disease from hydatidiform mole. Histological grading of hydatidiform mole did not show a good correlation with regard to the occurrence of secondary trophoblastic disease from hydatidiform mole.
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