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  • Title: Drug intoxication: influence of hemoperfusion on human plasma fibronectin.
    Author: Lohmann J, Pott G, Voss B, Gerlach U.
    Journal: Klin Wochenschr; 1983 Apr 01; 61(7):369-72. PubMed ID: 6865268.
    Abstract:
    Fibronectin is a glycoprotein belonging to the opsonic system and able to mediate phagocytosis by the reticuloendothelial system (RES). Severe intoxications are often followed by a diminished capacity of RES-clearance. Patients with severe drug intoxications have lower concentrations of fibronectin in plasma than healthy persons. Charcoal hemoperfusion lowers plasma fibronectin by an average of 4.7 mg/dl. Initial values below 15 mg/dl did not undergo a significant decrease in the case of hemoperfusion. Regarding these findings, determination of plasma fibronectin seems a useful parameter for monitoring RES function during treatment of drug-intoxicated patients by hemoperfusion.
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