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  • Title: Effects of morphine and opioid peptides on sensitivity to acetylcholine of dialysed snail neurons.
    Author: Gromov LA, Krivorotov SV, Skryma RN.
    Journal: Neuroscience; 1983 Apr; 8(4):855-60. PubMed ID: 6866266.
    Abstract:
    The effects of intracellular and extracellular applications of morphine (in concentrations from 10(-3) to 10(-5) M), leucine-enkephalin and methionine-enkephalin (10(-6) to 10(-8) M) were studied in unidentified acetylcholine-sensitive dialysed neurons of a snail under voltage clamp. Morphine produced inward membrane currents, while enkephalins did not. Both morphine and enkephalins altered the effect of acetylcholine on postsynaptic acetylcholine receptors; intracellular application of these substances being much more effective than extracellular application. This suggested that opioid peptides take part in the regulation of cholinergic synaptic transmission.
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