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  • Title: Diagnostic reliability of Mi-Mark helix technique in endometrial neoplasia.
    Author: Ginsberg NA, Padleckas R, Javaheri G.
    Journal: Obstet Gynecol; 1983 Aug; 62(2):225-30. PubMed ID: 6866365.
    Abstract:
    To evaluate the diagnostic reliability of the Mi-Mark helix technique in endometrial neoplasia, 138 women with abnormal uterine bleeding underwent a prospective study of Mi-Mark sampling of the uterine cavity before dilatation and curettage. Of one hundred thirty-eight patients, 42% had postmenopausal bleeding and 18% had perimenopausal bleeding. The acceptability of this procedure by patients and physicians was remarkable. All invasive endometrial carcinomas were detected by Mi-Mark cytology. The most serious limitation of this technique was its failure to detect a large number of hyperplasias without atypia. Examination of a cell block along with cytology would facilitate the histopathologic diagnosis, especially of hyperplasia. The results of this study appear to justify the use of this procedure in high-risk patients.
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