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  • Title: [Biochemical shifts in the nuclear membranes of the kidneys of dogs after the prolonged intravenous administration of amphotericin B].
    Author: Asinovskaia NK, Oksman AIa, Kravchenko LS, Tereshin IM.
    Journal: Antibiotiki; 1978 Aug; 23(8):731-6. PubMed ID: 686698.
    Abstract:
    The protein composition of the nuclear membranes of the dog kidneys after intravenous infusion of amphotericin B in a dose of 3 mg/kg and sodium desoxycholate in a dose of 1.2 mg/kg for 8 days was studied. It was found that administration of amphotericin B and sodium desoxycholate was accompanied by pronounced changes in the membrane proteins. The changes were evident from a decreased content of histones in the nuclear membranes, elimination of the high molecular components, a decreased quantitative content of some fractions and appearance of low molecular bands. The effect of sodium desoxycholate on the nuclear membrane proteins was shown to be less pronounced than that of amphotericin B. The significance of the data is discussed in connection with high toxicity of polyenic antibiotics. The data provide elucidation of the causes of the nephrotoxic effect of the polyenic antibiotics.
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