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  • Title: [Experimental study of the action of olivomycin on a melanoblastoma of the vascular tract of the eye].
    Author: Nifontova TP.
    Journal: Antibiotiki; 1978 Aug; 23(8):736-40. PubMed ID: 686699.
    Abstract:
    A total of 66 experiments were performed with a purpose of studying the effect of olivomycin on the melanoblastoma cells of the human eye vascular tract. Heterotransplants of the human eye vascular tract melanoblastoma in the anterior chamber of the rabbit eye served the objects of the studies. Olivomycin was used in 34 out of 66 experiments and 32 experiments were control. Separate tumor cells together with pronounced signs of necrosis were detected on histological examination only in 1 out of 34 transplants treated with olivomycin. The transplants in the other 33 experiments resolved. The transplant in the control experiments consisted of viable cells at the same period. On the basis of the experiments it was concluded that olivomycin had a pronounced destroying effect on melanoblastoma cells under conditions of heterotransplantation and may be recommended for clinical use for prophylaxis of metastasis in post-operative periods.
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