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  • Title: Time course of pimozide effects on brain stimulation reward.
    Author: Atalay J, Wise RA.
    Journal: Pharmacol Biochem Behav; 1983 Apr; 18(4):655-8. PubMed ID: 6867071.
    Abstract:
    Lever pressing for brain stimulation reward (BSR) was tested at hourly intervals following 0.5 or 1.0 mg/kg of pimozide given intraperitoneally. Response suppression was seen within one or two hours and peak effects occurred 5-8 hours after injection. Recovery approached completion within about 24 hours. Since peak brain levels of pimozide are reached quickly, the time course of peak action suggests a complex mechanism of pimozide action.
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