These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Mechanism of lithium action on the adrenergic function.
    Author: El-Koussi AA, Afifi AM, Abdel-Rahman MM.
    Journal: Pharmacol Res Commun; 1983 Apr; 15(4):397-407. PubMed ID: 6867075.
    Abstract:
    The intravenous injection of Lithium chloride (LiCl) in two dose levels (25 & 50 mg/kg) has led to a significant potentiation of the pressor response of rabbits to the i.v administration of both epinephrine and norepinephrine. The i.v injection of LiCl (50 mg/kg) resulted in a marked depression of the carotid occlusion reflex in rabbits. In vitro experiments revealed that LiCl (1.6 mcg/ml) and guanethidine (0.8 mcg/ml) exert the same action on the rabbit mesenteric nerve-intestine preparation and abolish the intestinal relaxation induced by electrical stimulation of the mesenteric nerve. Results confirm the assumption that Li might display a pre-synaptic, guanethidine-like, adrenergic neuronal blocking activity.
    [Abstract] [Full Text] [Related] [New Search]