These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Antihypoxic effect of tisochromide (16-244) in comparison with piracetam].
    Author: Ostrovskaya RU, Hoffmann W, Molodawkin GM, Rostock A.
    Journal: Pharmazie; 1983 Apr; 38(4):251-3. PubMed ID: 6867087.
    Abstract:
    The antihypoxic activity of Tisochromide (3-[4'-dimethylamino-4'-methylpentyl(2')-carbamoyl]-6,7-dimethoxy-1-thiaisochroman-1,1-dioxide), a substance of clinically antidepressant action, is studied on three hypoxia models and compared with that of the nootropic agent Piracetam: -- Tisochromide produces a dosis-dependent prolongation of the survival time of mice exposed to nitrogen hypoxia. -- The hypoxia-induced increase of lactate and pyruvate in the mouse brain is inhibited by this preparation. -- As to anoxia-induced electroencephalographic changes in the rat. Tisochromide increases the cerebral resistance against anoxia and shortens the isoelectric part of the encephalogram as well as the postanoxic phase of normalization.
    [Abstract] [Full Text] [Related] [New Search]