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  • Title: Effect of chronic sympathetic denervation upon the transcapillary filtration rate induced by venous stasis.
    Author: Henriksen O, Sejrsen P, Paaske WP, Eickhoff JH.
    Journal: Acta Physiol Scand; 1983 Feb; 117(2):171-6. PubMed ID: 6869029.
    Abstract:
    The effect of venous pressure elevation upon capillary filtration rate in the limb was studied in 6 chronically sympathectomized patients. Five healthy subjects served as controls. Volume changes of the forearm or calf were recorded by a strain-gauge plethysmograph. Relative blood flow in subcutaneous and muscle tissue during venous stasis was measured by the local 133Xe washout technique. In the denervated limbs there was a linear relationship between net capillary filtration rate and venous pressure elevation. In the controls a non-linear relationship was seen as venous pressure elevation of 40 mmHg only caused an increase in net filtration rate of about 66% of that expected from a linear relationship. In the denervated limbs of blood flow in muscle and subcutaneous tissue remained constant during venous pressure elevation of more than 30 mmHg whereas in the non-denervated limbs blood flow decreased by about 50% in both tissues. The results suggest that a local sympathetic veno-arteriolar (axon) reflex plays a dominant role for the reduced increase in net capillary filtration during large increases in venous pressure. The local axon reflex may therefore act as an edema protecting factor.
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