These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Maternal and fetal cardiovascular indices during fetal hypoxia due to cord compression in chronically cannulated sheep. II. Responses to promazine.
    Author: Cottle MK, Van Petten GR, van Muyden P.
    Journal: Am J Obstet Gynecol; 1983 Jul 15; 146(6):686-92. PubMed ID: 6869439.
    Abstract:
    Promazine (Sparine) administered to chronically cannulated pregnant ewes caused significant maternal and fetal tachycardia and hypotension, depressed uterine blood flow and fetal Pao2, and increased fetal Paco2. When the drug was given before brief compression of the umbilical cord, uterine flow was more depressed than by compression alone, the fetal pressor response was attenuated, and fetal posthypoxia tachycardia was augmented. We conclude that promazine taken by a mother could have especially deleterious effects on her fetus when the latter's oxygenation is already depressed (e.g., by cord compression), and suggest that the use of promazine during labor be reevaluated.
    [Abstract] [Full Text] [Related] [New Search]