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  • Title: [Effect of pyridoxylate on the intensity of changes in the internal organs and skeletal musculature of rats under considerable physical loading].
    Author: Megrelishvili RI, Glezer GA, Ryff IM, Sharov VG, Cherpachenko NM.
    Journal: Arkh Patol; 1978; 40(5):53-60. PubMed ID: 686990.
    Abstract:
    Under considerable physical load, marked enzymopathy, increased permeability of cellular membranes with the involvement of cellular and subcellular structures develop in the myocardium, skeletal musculature and viscera of rats. Administration of pyridozylate decreases the intensity of damage reactions and normalizes to a certain degree the structure of cellular and subcellular elements of tissues. This indicates the advisability of the employment of the cell respiration regulators under conditions of general and tissue hypoxy and metabolic shifts.
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