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  • Title: Studies on the subcellular localization and role of glutathione-insulin transhydrogenase in rat liver.
    Author: Chowdhary BK, Smith GD, Mahler R, Peters TJ.
    Journal: Biosci Rep; 1983 Apr; 3(4):323-9. PubMed ID: 6871380.
    Abstract:
    125I-insulin was shown to be internalized in vivo to a discrete population of low-density membranes (ligandosomes), distinct from the +Golgi, endoplasmic reticulum, plasma membrane, and lysosomes. However, analytical subcellular fractionation shows that glutathione-insulin transhydrogenase is localized to the endoplasmic reticulum. Measurement of the specific enzyme activity of glutathione-insulin transhydrogenase showed no differences between normal, diabetic, and hyperinsulinaemic rats. These results suggest that glutathione-insulin transhydrogenase is not directly involved in the subcellular processing of receptor-bound internalized insulin.
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