These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: GABA inhibition of central angiotensin II and hypertonic CSF pressor responses.
    Author: Brennan TJ, Haywood JR.
    Journal: Brain Res; 1983 May 16; 267(2):261-9. PubMed ID: 6871675.
    Abstract:
    Angiotensin II (AII), hypertonic cerebrospinal fluid (CSF) and serotonin produced an increase in arterial pressure when administered intraventricularly (IVT) in conscious rats. Injection of 25 and 100 micrograms (IVT) of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), while producing slight hypotension, reduced the pressor effect of centrally administered AII and hypertonic CSF, but not serotonin. IVT-administered muscimol, a potent GABA agonist, also attenuated the pressor effect of IVT AII and hypertonic CSF. Thus, in addition to the profound depressor effect of large doses of centrally administered GABA, very low doses (25-100 micrograms, IVT) of this amino acid can alter the pressor responses caused by IVT injection of AII and hypertonic CSF.
    [Abstract] [Full Text] [Related] [New Search]