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  • Title: Development of a carcinogen-induced rat colon cancer with lymph-node metastases.
    Author: Weese JL, Starling JR, Turner JH.
    Journal: Dis Colon Rectum; 1983 Sep; 26(9):573-7. PubMed ID: 6872786.
    Abstract:
    The progression from normal colonic mucosa to invasive adenocarcinoma of the colon with lymph-node metastases was documented in Sprague-Dawley rats receiving 30 mg of N-methyl-N-nitrosourea via intrarectal injections. Histologically, these tumors closely resemble human colonic cancer. This model is predictable and reproducible. It offers a genetically nonidentical rat model for the development of cancer biology and therapy models.
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