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  • Title: Ultrastructural appearances of interstitial tissue of testis in vasectomised individuals.
    Author: Mehrotra R, Nath P, Tandon P, Singh KM, Kumar H.
    Journal: Indian J Med Res; 1983 Mar; 77():347-52. PubMed ID: 6874016.
    Abstract:
    In order to study the light and electron microscopic features of the interstitial tissue of the testis in vasectomized men, testicular biopsies were obtained using local anesthesia from 5 men ages 20-32 who had reported for vasovasostomy. Time interval between vasectomy and biopsy ranged from 1.5-5 years. Light microscopy showed increase in interstitial tissue in 3 of the 5 cases due to proliferation of loose fibrous tissue which was uniformly distributed between the seminiferous tubules in 2 cases while in the other cases it was aggregated focally. The seminiferous tubules in all the cases were distended, tortuous, and hypocellular. The lamina propria was thickened and the blood capillaries and Leydig cells did not reveal any alterations. These findings show that vasectomy does not produce any significant morphological alterations in the Leydig cells; this confirms the reports that both in man and rhesus monkeys no significant changes in the levels of testosterone or luteinizing hormone occur after vasectomy. It is also found that Leydig cells may degenerate and release their crystalloids and other inclusions into the extracellular space of the interstitial tissue in normal individuals as well.
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