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  • Title: Estrogen receptor-mediated cytotoxicity using iodine-125.
    Author: Bloomer WD, McLaughlin WH, Milius RA, Weichselbaum RR, Adelstein SJ.
    Journal: J Cell Biochem; 1983; 21(1):39-45. PubMed ID: 6874726.
    Abstract:
    Auger effects from 125I decay are singularly damaging if localized in DNA as the thymidine analogue 125I-iododeoxyuridine (125IUdR). Recent experience with steroid sex hormones extends these observations by demonstrating cytotoxicity in sites other than the DNA backbone. We have compared the cytotoxicity in human MCF-7 breast cancer cells of 125IUdR, 125I-iodotamoxifen, a nonsteroidal antiestrogen that is translocated from the cytoplasm to the nucleus of receptor containing cells, and 125I-iodoantipyrine, a biological indicator of the body water space. Cytotoxicity is critically dependent upon subcellular localization.
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