These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Nascent hepatic lipoproteins in hypothyroid rats.
    Author: Dolphin PJ, Forsyth SJ.
    Journal: J Lipid Res; 1983 May; 24(5):541-51. PubMed ID: 6875379.
    Abstract:
    Cholesterol-feeding of hypothyroid Long-Evans rats results in a marked hypercholesterolemia and hepatic secretion of cholesteryl ester and apoE-rich VLDL and LDL which accumulate in the serum compartment (J. Lipid Res. 1981 22: 971-989). The present study segregates the effects of hypothyroidism from the combined effects reported above. Hypothyroidism alone does not result in the secretion of cholesteryl ester-rich lipoproteins by the liver which, in contrast, contains depressed quantities (30%) of triglyceride-rich (71% of lipid mass) VLDL and low levels of LDL which is also triglyceride-rich when compared to the nascent lipoproteins of euthyroid rat livers. The nascent lipoproteins from the hepatic Golgi cisternae and secretory vesicles of hypothyroid rats all had pre-beta or slow pre-beta migration on agarose gel electrophoresis and were very dissimilar in lipid and apoprotein composition from the beta-migrating LDL that accumulates in the sera of these animals and contains 13.8% triglyceride, 51.3% cholesteryl ester, and has an apoB/apoE ratio of 32.7. We conclude that the serum LDL in hypothyroid rats, which contains only apoB100, is not secreted directly by the liver but represents a normal catabolite of triglyceride-rich VLDL that may accumulate due to reduced receptor-mediated clearance rather than an overproduction of its immediate precursor, hepatic VLDL.
    [Abstract] [Full Text] [Related] [New Search]