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  • Title: Plasma testosterone in molar pregnancy: Correlation with gestational age, uterine size, theca-lutein cyst and serum HCG.
    Author: Chew PC, Ratnam SS, Goh HH.
    Journal: Br J Obstet Gynaecol; 1978 Aug; 85(8):624-6. PubMed ID: 687543.
    Abstract:
    Plasma testosterone and serum HCG were measured by radioimmunoassay in 46 patients with intact molar pregnancy. There was no significant difference in plasma testosterone between patients with theca-lutein cyst and those without the cyst. This suggests that ovarian contribution to the elevated testosterone in molar pregnancy is probably a minor one. No correlation was found between plasma testosterone and uterine size. However, a positive correlation (r=+0.3567, P less than 0.001) was found between plasma testosterone and the HCG and a rising trend in plasma testosterone was observed with increasing gestation. These results suggest that molar trophoblast is probably the major source of elevated testosterone in the maternal circulation.
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