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  • Title: Contractions induced by sodium withdrawal in crab (Callinectes danae) muscle fibres.
    Author: Madeira AC, Suarez-Kurtz G.
    Journal: J Physiol; 1983 May; 338():339-53. PubMed ID: 6875961.
    Abstract:
    A study was made of the effects of Na removal on the resting tension of single muscle fibres of the crab Callinectes danae. Reduction of [Na]o (replacement with Li, Tris or choline) below a threshold value, typical for each fibre, induced spontaneous, local contractions randomly dispersed along the fibres; this was followed by propagated contractile waves and tension oscillations. Sustained contractures were occasionally seen at threshold [Na]o and were consistently observed when [Na]o was further reduced. The Na withdrawal contractions depended on [Ca]o and were abolished in Ca-free media; they were restored within seconds after the addition of Ca (3-12 mM) or Sr (15-25 mM), but not Ba (10-100 mM), to the media. Caffeine (0.2-1.0 mM) facilitated, whereas La (2-5 mM), procaine (1 mM) or lidocaine (10 mM) inhibited the Na-withdrawal contractions. It is concluded that increased Ca influx across the sarcolemma and release of stored Ca from the sarcoplasmic reticulum are involved in the contractions induced by Na-deficient solutions in crab fibres.
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