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  • Title: Nitrogen bridgehead compounds. 33. New antiallergic 4H-pyrido[1,2-a]pyrimidin-4-ones. 2.
    Author: Hermecz I, Breining T, Mészáros Z, Kökösi J, Mészáros L, Dessy F, DeVos C.
    Journal: J Med Chem; 1983 Aug; 26(8):1126-30. PubMed ID: 6876080.
    Abstract:
    A series of 9-hydrazono-4H-pyrido[1,2-a]pyrimidin-4-ones was prepared. The compounds were evaluated in the rat passive cutaneous anaphylaxis test for antiallergic activity. Structure-activity relationship studies revealed that the presence of a monosubstituted hydrazone moiety in position 9 and an unsubstituted 2-position are necessary for the intravenous activity.
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