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  • Title: [Biological and clinical analysis of breast cancer in relation to hormone receptors].
    Author: Akagi M, Iwaki J, Kimura M, Kihara S, Maeno M, Nishimura R, Araki K, Egami H, Yamashita J, Shigaki N, Fujino N.
    Journal: Gan No Rinsho; 1983 May; 29(6):632-6. PubMed ID: 6876432.
    Abstract:
    We examined whether or not the presence of hormone receptors (ERC, PRC, and ERN) were related to morphological and functional features in breast cancers. Well-differentiated tumors were more frequently receptor positive while poorly differentiated tumors were generally receptor negative. And labelling index and receptor contents were negatively correlated. There was a significant inverse correlation between the receptor contents and numbers of intracellular organellas in ultrastructural features of breast cancer cells. In LMI tests by 3-M KCl cancer extracts, migration of leucocyte from patients with poorly differentiated tumors were more frequently inhibited than those well differentiated tumors. Patients with receptor positive tumors were more endocrine sensitive and had better prognosis.
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