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  • Title: High-dose cyclophosphamide and adriamycin with DTIC maintenance for metastatic soft tissue sarcomas.
    Author: Clamon G, Sinkey C, Jochimsen P.
    Journal: J Surg Oncol; 1983 Aug; 23(4):282-4. PubMed ID: 6876805.
    Abstract:
    Intensive chemotherapy with high-dose cyclophosphamide and adriamycin with DTIC maintenance was given to 12 patients with metastatic soft tissue sarcomas. A partial response rate of 25% was seen; this is no better than can be achieved with single-agent therapy. Because of substantial toxicity without improved efficacy, the trial of high dose therapy was halted.
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