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  • Title: Effects of pharmacologic agents on umbilical blood flow in fetal lambs in utero.
    Author: Berman W, Goodlin RC, Heymann MA, Rudolph AM.
    Journal: Biol Neonate; 1978; 33(5-6):225-35. PubMed ID: 687691.
    Abstract:
    We studied the effects of pharmacologic agents on umbilical blood flow and umbilical-placental vascular resistance in 18 fetal lambs in utero. Three groups of drugs were identified: the first had no effect on umbilical blood flow or umbilical-placental vascular resistance; the second altered umbilical blood flow secondary to changes in heart rate and placental perfusion pressure, but did not change umbilical-placental vascular resistance; the third decreased umbilical blood flow and increased umbilical-placental vascular resistance. The studies suggest mechanisms by which umbilical blood flow is regulated in the fetal lamb.
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