These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Potentiation by an alpha-adrenolytic agent, nicergoline, of the cardiac effects of propranolol.
    Author: Boismare F, Moore N, Decourt S, Paux G, Saligaut C, Chretien P.
    Journal: Methods Find Exp Clin Pharmacol; 1983; 5(2):83-8. PubMed ID: 6876944.
    Abstract:
    Ten young healthy volunteers were given placebo, propranolol (20 or 40 mg), nicergoline, an alpha blocking agent (30 mg) or the association of nicergoline (15 mg) and propranolol (20 mg) in a randomized double blind study. The results show that nicergoline potentiates the cardiodepressant action of propranolol, whereby the effects of 20 mg become the same as those of 40 mg given alone on cardiac output and myocardial oxygen demand, though the plasma propranolol levels are not changed. We, therefore, propose that nicergoline blocks alpha 1 agonist effects of propranolol, which are usually masked by the greater beta 1 blocking effects but could have clinical and therapeutic relevance.
    [Abstract] [Full Text] [Related] [New Search]