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  • Title: Presence of 3-amino-beta-carbolines (3-amino-9H-pyrido[3,4-b]indoles), effectors in the induction of sister-chromatid exchanges, in protein pyrolysates.
    Author: Tada M, Saeki H, Oikawa A.
    Journal: Mutat Res; 1983 Aug; 121(2):81-8. PubMed ID: 6877271.
    Abstract:
    3-Amino-9H-pyrido[3,4-b]indole (3-aminonorharman) and 3-amino-1-methyl-9H-pyrido[3,4-b]indole (3-aminoharman), effectors for induction of sister-chromatid exchanges in human lymphoblastoid cells, were identified in pyrolysates of casein by high-performance liquid chromatography and UV spectrophotometry, together with some other mutagenic/carcinogenic carbolines. In pyrolysates from a preparation of zein, which contained little tryptophan, only norharman and harman were found in small amounts.
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