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Title: Cryptococcal meningitis in pregnancy. Author: Stafford CR, Fisher JF, Fadel HE, Espinel-Ingroff AV, Shadomy S, Hamby M. Journal: Obstet Gynecol; 1983 Sep; 62(3 Suppl):35s-37s. PubMed ID: 6877708. Abstract: Cryptococcal meningitis was diagnosed in a pregnant woman at 21 weeks' gestation. The availability of fetal tissues, blood, and amniotic fluid in such a patient receiving therapy with amphotericin B plus flucytosine afforded the opportunity to study the effects of the disease and therapeutic agents on the developing fetus. The amphotericin B concentration in amniotic fluid was 0.25 micrograms/ml and that of flucytosine was 168 micrograms/ml. The concentrations in cord blood were 0.3 micrograms/ml and 64.7 micrograms/ml, respectively. No evidence was found of amphotericin B or flucytosine toxicity in fetal tissues, although exposure of the fetus to these compounds was of brief duration.[Abstract] [Full Text] [Related] [New Search]