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  • Title: Morphologic and functional tubular changes in chronic glomerulonephritis.
    Author: Klinkmann H, Ratner M, Serov VV, Nizze H, Rosenfeld BI, Sinn W, Schmicker R.
    Journal: Proc Eur Dial Transplant Assoc; 1983; 19():679-85. PubMed ID: 6878260.
    Abstract:
    In 135 patients with different glomerular diseases but normal glomerular filtration rates (CCr and In = 103 +/- 2ml/min) correlations between morphological tubular lesions (tic) and changes in tubular function were investigated. Between the extent of tubular lesions and the impairment of specific tubular functions (formula; see text) exists a highly significant correlation. The combined diminution in Uosmmax and UNH4 + V reflects in 72 per cent the appearance of a severe tubular lesion and should be used for its clinical recognition.
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