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  • Title: Heparin-like activity in uterine fluid.
    Author: Foley ME, Griffin BD, Zuzel M, Aparicio SR, Bradbury K, Bird CC, Clayton JK, Jenkins DM, Scott JS, Rajah SM, McNichol GP.
    Journal: Br Med J; 1978 Jul 29; 2(6133):322-4. PubMed ID: 687899.
    Abstract:
    Uterine fluid was collected from a group of normal patients and a group of patients with menorrhagia. Heparin-like activity was detected in 34 out of 38 samples using an anti-Xa heparin assay. The heparin-like activity in uterine fluid was inhibited by adding the heparin antagonist hexadimethrine bromide to the assay. Concentrations of fibrinogen-fibrin degradation products (FDPs) were measured in five samples of uterine fluid. FDPs in the concentration detected had no effect on the anti-Xa assay. Heparin-like activity was higher in the group with menorrhagia, although the differences were not significant. Heparin-like activity increased throughout the menstrual cycle and decreased during menstruation, suggesting a possible cyclical variation in activity. There was no correlation between mast cell numbers in the endometrium and myometrium and heparin-like activity in uterine fluid and no correlation between the numbers and the stage in the menstrual cycle. In a few patients with intrauterine contraceptive devices (IUCDs) heparin-like activity was increased.
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