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  • Title: [Isolated hypothyroid dwarfism. Study of 18 cases].
    Author: Dessart Y, Chaussain JL, Job JC.
    Journal: Arch Fr Pediatr; 1983 May; 40(5):375-8. PubMed ID: 6882126.
    Abstract:
    Isolated hypothyroid dwarfism is defined by growth retardation without other clinical symptoms or signs of thyroid insufficiency. This study reports 18 cases: 6% of a series of cases of hypothyroidism in childhood. The main features are: mean bone age lower than height age; low plasma thyroxine in 16 patients, definitely low triiodothyronine in one only, high plasma TSH in all cases, with exaggerated response to TRH stimulation test; enlarged sella turcica in 11 patients. The thyroid gland was ectopic in 14 patients, the 4 others had a thyroid in normal place. Treatment with thyroid hormones sharply increased the growth velocity and the bone maturation. However its delay did not allow to obtain a complete catch-up of height.
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